Python is a versatile, highly used language and can also be used for smart contractsweb3 development; web3.py is a compelling Python library that fulfills web3 needs. Brownie framework is built on top of web3.py. After the installation of TestRPC and Web3.js create a smart contract which you want to connect with Web3.js. Step 1 Open Remix-IDE. Step 2 Create a sample smart contract as shown below or create any other smart contract. Step 3 Compile your code and move to. Under the project root folder (hello-eth) create a file named app.py with the following content (pay attention to the comments explaining the script). Using Truffle and Ganache for Ethereum development environment setup. Web3.py helps to integrate. Contract application binary interface (ABI) (opens new window) is used to encode different types of data while interacting with Ethereum contracts. As a result, both Solidity and modules such as web3.js (opens new window) and ethers.js (opens new window) treat ABI encodingdecoding functionality as a first-class citizen.